MAPK4 (Vector pUC, Accession No. BC117216)

Length: 1764 Sequence: atggctgaga agggtgactg catcgccagt gtctatgggt atgacctcgg tgggcgcttt gttgacttcc aacccctggg cttcggtgtc aatggtttgg tgctgtcggc cgtggacagc cgggcctgcc ggaaggtcgc tgtgaagaag attgccctga gcgatgcccg cagcatgaag cacgcgctcc gagagatcaa gatcattcgg cgcctggacc acgacaacat cgtcaaagtg tacgaggtgc tcggtcccaa gggcactgac ctgcagggtg agctgttcaa gttcagcgtg gcgtacatcg tccaggagta catggagacc gacctggcac gcctgctgga gcagggcacg ctggcagaag agcatgccaa gctgttcatg taccagctgc tccgcgggct caagtacatc cactccgcca acgtgctgca cagggacctg aagcccgcca acatcttcat cagcacagag gacctcgtgc tcaagattgg ggatttcggg ttggcaagga tcgttgatca gcattactcc cacaagggtt atctgtcaga agggttggta acaaagtggt accgttcccc acgactgctc ctttccccca ataactacac caaagccatc gacatgtggg ccgccggctg catcctggct gagatgctta cggggagaat gctctttgct ggggcccatg agctggagca gatgcaactc atcctggaga ccatccctgt aatccgggag gaagacaagg acgagctgct cagggtgatg ccttcctttg tcagcagcac ctgggaggtg aagaggcctc tgcgcaagct gctccctgaa gtgaacagtg aagccatcga ctttctggag aagatcctga cctttaaccc catggatcgc ctaacagctg agatggggct gcaacacccc tacatgagcc catactcgtg ccctgaggac gagcccacct cacaacaccc cttccgcatt gaggatgaga tcgacgacat cgtgctgatg gccgctaacc agagccagct gtccaactgg gacacgtgca gttccaggta ccctgtgagc ctgtcgtcgg acctggagtg gcggcctgac cggtgccagg acgccagcga ggtacagcgc gacccgcgcg cgggttcggc gccactggct gaggacgtgc aggtggaccc gcgcaaggac tcgcacagca gctccgagcg cttcctagag cagtcgcact cgtccatgga gcgcgccttc gaggccgact acgggcgctc ctgcgactac aaggtggggt cgccgtccta cctggacaag ctgctgtggc gcgacaacaa gccgcaccac tactcggagc ccaagctcat cctggacctg tcgcactgga agcaggcggc cggcgcgccc cccacggcca cggggctggc ggacacgggg gcgcgcgagg acgagccggc cagcctcttc ctggagatcg cgcagtgggt caagagcacg cagggcggcc cagagcacgc cagcccgccc gccgacgacc ccgagcgccg cttgtctgcc tcgccccccg gccgcccggc cccggtggac ggcggcgcca gcccccagtt cgacctggac gtgttcatct cccgcgccct gaagctctgc accaagcccg aggacctgcc ggacaataaa ctgggcgacc tcaatggtgc gtgcatcccc gagcaccctg gcgacctcgt gcagaccgag gccttctcca aagaaaggtg Protein function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. [The UniProt Consortium]