LZTR1 (Vector pUC, Accession No. BC026214)

Length: 1659 Sequence: atggtggcct ttgaccgcca cctctatgtg tttgggggtg cggccgacaa cacgctgccc aacgagctgc actgctatga cgtggacttc cagacctggg aggtcgtcca gcccagctcc gacagcgagg ttggtggggc tgaagtgccc gagcgagcct gtgcttccga ggaggtgccc accctgacct atgaggagcg ggttggcttc aagaagtccc gagatgtgtt tggcctggac tttggcacca cctcagccaa gcagcccacc cagcctgcct cggagctgcc cagtgggagg ctcttccacg cggctgctgt catctcggac gccatgtaca tcttcggggg cacggtggac aacaacatcc gcagcgggga gatgtacagg ttccagttct cctgttaccc taaatgcacg ctgcacgagg actacgggcg gctgtgggag agccgccagt tctgcgacgt ggagttcgtg ctgggtgaga aggaggagtg cgtgcagggc cacgtagcca ttgtcacagc gcggagccgc tggcttcgca ggaagatcac gcaggcgcgg gagaggctgg cccagaagct ggagcaggag gccgccccag ttcccaggga ggcccccggc gtggctgctg gtggggcccg gccgcccctg ctgcacgtgg ccatccggga ggccgaggcc cggcccttcg aggtgctcat gcagttcctc tacaccgaca agatcaaata cccacggaaa ggccatgtgg aggatgtgct gctcatcatg gatgtgtaca aactggcact gagcttccag ttgtgccgtc tggagcagct gtgccgccag tacatcgagg cctccgtgga cctgcagaac gtgctggttg tgtgcgagag tgccgcccgg ctgcagctga gccaactcaa ggagcactgc ctgaacttcg tggtaaagga gtcccacttc aaccaggtga tcatgatgaa ggagttcgag cgcctctcct ctccactgat agtggagatt gtgcggcgga agcagcagcc gccccctcgc actcccttgg accagccagt ggacattggc acatctctga tccaggacat gaaggcatac ctggagggag cgggcgcgga attctgtgac atcactctgt tgcttgacgg gcacccacgg ccagcccaca aggctatcct ggccgcccgc tccagctact ttgaagccat gttccggtcc ttcatgcccg aagatgggca ggtgaacatc tccatcgggg agatggtgcc cagcaggcag gccttcgagt ccatgctgcg ctacatctac tacggcgagg tcaacatgcc gcccgaggac tcgctctact tgtttgcggc cccctactac tacggcttct acaacaaccg gctgcaggcg tactgcaagc agaacctgga gatgaacgtg acggtgcaga acgtgctgca gatcctggag gcagctgaca aaacgcaggc actggacatg aagcggcact gcctgcacat cattgtgcac cagttcacca aggtctccaa gttgcccacc ctgcggtcgc tgagccagca gctgctgctg gacatcatag actccctggc ctcccacatc tcagacaagc agtgcgcaga gctgggcgcc Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304). [The UniProt Consortium]