LMBR1L (Vector pENTR223.1, Accession No. BC015015)

Length: 1470 Sequence: atggaagcac ctgactacga agtgctatcc gtgcgagaac agctattcca cgagaggatc cgcgagtgta ttatatcaac acttctgttt gcaacactgt acatcctctg ccacatcttc ctgacccgct tcaagaagcc tgctgagttc accacagtgg atgatgaaga tgccaccgtc aacaagattg cgctcgagct gtgcaccttt accctggcaa ttgccctggg tgctgtcctg ctcctgccct tctccatcat cagcaatgag gtgctgctct ccctgcctcg gaactactac atccagtggc tcaacggctc cctcatccat ggcctctgga accttgtttt tctcttctcc aacctgtccc tcatcttcct catgcccttt gcatatttct tcactgagtc tgagggcttt gctggctcca gaaagggtgt cctgggccgg gtctatgaga cagtggtgat gttgatgctc ctcactctgc tggtgctagg tatggtgtgg gtggcatcag ccattgtgga caagaacaag gccaacagag agtcactcta tgacttttgg gagtactatc tcccctacct ctactcatgc atctccttcc ttggggttct gctgctcctg gtgtgtactc cactgggtct cgcccgcatg ttctccgtca ctgggaagct gctagtcaag ccccggctgc tggaagacct ggaggagcag ctgtactgct cagcctttga ggaggcagcc ctgacccgca ggatctgtaa tcctacttcc tgctggctgc ctttagacat ggagctgcta cacagacagg tcctggctct gcagacacag agggtcctgc tggagaagag gcggaaggct tcagcctggc aacggaacct gggctacccc ctggctatgc tgtgcttgct ggtgctgacg ggcctgtctg ttctcattgt ggccatccac atcctggagc tgctcatcga tgaggctgcc atgccccgag gcatgcaggg tacctcctta ggccaggtct ccttctccaa gctgggctcc tttggtgccg tcattcaggt tgtactcatc ttttacctaa tggtgtcctc agttgtgggc ttctatagct ctccactctt ccggagcctg cggcccagat ggcacgacac tgccatgacg cagataattg ggaactgtgt ctgtctcctg gtcctaagct cagcacttcc tgtcttctct cgaaccctgg ggctcactcg ctttgacctg ctgggtgact ttggacgctt caactggctg ggcaatttct acattgtgtt cctctacaac gcagcctttg caggcctcac cacactctgt ctggtgaaga ccttcactgc agctgtgcgg gcagagctga tccgggcctt tgggctggac agactgccgc tgcccgtctc cggtttcccc caggcatcta ggaagaccca Protein function: Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway. In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6. LMBR1L stabilizes the beta- catenin destruction complex that is required for regulating CTNNB1 levels. Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685). [The UniProt Consortium]