LIMD1 (Vector pUC, Accession No. BC117236)

Length: 2031 Sequence: atggataagt atgacgacct gggcctggag gccagtaaat tcatcgagga cctgaacatg tatgaggcct ctaaggatgg gctcttccga gtggacaagg gtgcaggcaa caaccccgag tttgaggaaa ctcgcagggt gttcgccacc aagatggcca aaatccacct ccagcagcag cagcagcagc tcctgcagga ggagactctg cccaggggga gtagaggccc tgtcaatgga gggggccgcc tgggcccaca ggcccgttgg gaagttgtgg gcagcaagct gactgtggat ggtgctgcca agcctcctct tgctgcctcg acaggggcac ctggggcagt caccaccctc gctgctgggc agcccccgta cccaccgcag gagcagagat ccaggccata cctgcatggc acgaggcatg gcagccagga ctgtggttcc agggagagcc tggcgacttc tgagatgtct gctttccacc agccaggccc ctgtgaggat ccttcctgcc tcactcatgg agactattat gacaacctct ccttggcaag cccaaagtgg ggtgacaaac caggagtgtc ccccagcatc ggcctgagtg tagggagtgg gtggcctagc tccccgggga gtgacccacc actgcccaaa ccctgcgggg accatcccct aaatcaccga cagctctccc tgagctccag caggtcttct gagggtagcc tcggtggtca gaatagtggc attggtggcc gcagcagcga gaagccaaca ggcctttggt ccactgcctc ctcccagcgg gtgagccctg gcctgccttc cccaaacttg gagaacggag caccagctgt ggggcctgtt cagcccagga ctccttctgt gtcagcaccc ttggccctga gctgccccag gcaaggaggt cttccaagat caaactcggg gctggggggt gaggtttcag gtgtgatgtc caaacccaat gtggaccccc aaccctggtt ccaggatggg cccaaatctt acctttccag ttctgccccg tcatcctcgc cagctggcct ggacggttca cagcagggtg cggtccctgg gctggggccg aagcctggct gcacagacct tggcactggt cccaagctca gccccaccag tcttgtccat ccagtgatgt ccaccctgcc tgagttatct tgtaaagagg gtcccctggg ctggtcttct gatggtagcc tgggatctgt gctcctggac agccccagct cccctagggt aaggctgccc tgccagcccc tcgtcccagg tcctgagctg agaccctctg ctgctgagtt gaaattagaa gccctcaccc aacgtctgga gcgagagatg gatgctcacc cgaaggctga ttactttgga gcctgtgtga aatgcagcaa aggggtgttt ggggctggcc aggcctgtca ggccatgggg aacctctacc atgacacatg cttcacctgt gcagcttgca gccggaagct gagaggaaaa gccttttatt ttgtcaacgg caaagtgttt tgtgaagaag acttcctgta ctctggtttc cagcagtcgg ctgacaggtg ttttctttgt ggacatctga tcatggacat gatcctgcaa gccctgggga agtcctacca ccccggctgt ttccgctgtg tcatctgtaa tgagtgtttg gatggggtgc ccttcaccgt ggactcagag aacaagatct actgtgtccg agattaccac aaggtgctgg cccccaagtg tgcagcctgt gggcttccca tccttccacc tgagggctca gatgagacca tccgtgtcgt gtccatggac agagactacc acgtggagtg ttaccactgc gaggactgtg gtctggagct caatgatgaa gatggccacc gctgttatcc gctggaggac cacctgttct gtcactcctg ccacgtgaag aggctggaga agagaccctc atctacagcc cttcaccagc accacttcta Protein function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. [The UniProt Consortium]