KLHL25 (Vector pUC, Accession No. BC028100)

Length: 1770 Sequence: atgtcggtca gtgtccatga gacccgcaag tcgcggagca gcacggggtc catgaacgtc accctcttcc acaaggcctc ccacccggac tgtgtgctgg cccacctcaa cacgcttcgc aagcactgca tgttcaccga cgtcacactc tgggcgggcg accgtgcctt cccctgtcac cgtgccgtgc tggccgcctc tagccgctat tttgaggcca tgttcagcca tggccttcgg gagagccggg atgacactgt caacttccag gacaacctgc acccggaggt gctggagctg ctgctggact ttgcctactc ctcacgcatc gccatcaacg aggagaacgc tgagtcactg ctggaggcag gcgacatgct gcagttccac gatgtgcggg atgctgccgc cgagttcctg gagaagaacc ttttcccctc caactgcctg ggcatgatgc tgctctcgga cgcccaccag tgccgccggc tgtatgagtt ctcctggcgc atgtgcctgg tgcactttga gacggtgagg cagagcgagg acttcaacag cctgtccaag gacacactgc tggacctcat ctcgagtgat gagctggaga ccgaggacga gcgggtggtc ttcgaggcca tcctccagtg ggtgaagcac gacctggagc cacggaaggt ccacttgccc gagctcctcc gcagcgtgcg tctggccttg ctgccgtccg actgcctgca ggaggccgtc tccagcgagg ccctcctcat ggcagacgag cgcaccaagc ttatcatgga tgaggccctg cgctgcaaga ccaggatcct gcagaatgat ggcgtggtca ccagcccctg tgcccggcca cgcaaggcgg gccacacgct actcatcctg gggggccaga ccttcatgtg tgacaagatc taccaggtgg accacaaggc caaggagatc atccccaagg ccgacctgcc cagcccccgg aaggagttca gcgcctcagc gatcggctgc aaggtctatg tgacgggggg caggggctcc gagaacgggg tctccaagga tgtctgggtg tacgacaccg tacatgagga atggtccaag gcggcgccca tgctgattgc ccgctttggc catggctcag ctgagctgga gaactgcctc tatgtggtgg ggggacacac atccctggca ggggtcttcc cggcctcgcc ttctgtctcc ctgaaacaag tggagaaata cgaccctggg gccaacaagt ggatgatggt ggcccccttg cgggatggcg tcagcaatgc cgcagtggtg agtgccaagc tgaagctctt tgttttcgga ggaaccagca tccaccggga catggtgtcc aaggtccagt gctatgaccc ctcggagaac aggtggacga tcaaggccga gtgcccccag ccttggcggt acacagccgc tgccgtcctg ggcagccaga tcttcatcat gggaggtgac acggaattca cagccgcctc ggcctaccgc tttgactgtg agaccaacca gtggacgcgg attggggaca tgactgccaa gcgcatgtcc tgccatgccc tggcttccgg caacaagctc tatgtggtcg ggggctactt tgggacccag aggtgtaaga ctctggactg ctatgacccc acttcagata catggaactg catcaccaca gtgccctact cacttatccc cacggccttt gtcagcacct ggaagcacct Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. [The UniProt Consortium]