GGT5 (Vector pUC, Accession No. BC011362)

Length: 1761 Sequence: atggcccggg gctacggggc cacggtcagc ctagtcctgc tgggtctggg gctggcgctg gctgtcattg tgctggctgt ggtcctctct cgacaccagg ccccatgtgg cccccaggcc tttgcccacg ctgctgttgc cgccgactcc aaggtctgct cggatattgg acgagccatc ctccagcagc agggctcacc cgtggatgcc accatcgcgg ctctggtctg caccagcgtc gtcaaccctc agagcatggg cctgggcgga ggggtcatct tcaccatcta caatgtgaca acagggaagg tggaggtcat caatgcccgg gagacggtgc cggccagcca cgccccgagc ctgctggacc agtgtgcaca ggctctgcca ctgggcacag gggcccagtg gatcggggtg cccggggagc tccgtggcta tgccgaggcc caccgccgcc atggccgcct gccctgggcg cagctgttcc agcccaccat cgcgctgctc cgaggggggc atgtggtggc ccctgtcctc agccgtttcc tgcacaacag catcctgcgg ccttccttgc aggcgtcaac cctgcgccag ctcttcttca acgggacaga acccctgagg cctcaggacc cactcccatg gcctgcactg gccaccaccc tggagaccgt ggccacagag ggcgtggagg tcttctacac ggggaggctg ggccagatgc tggtggagga cattgccaag gaagggagcc agctgacgct gcaggacctg gccaagttcc agcccgaggt ggtggatgcc ctggaggtgc ccctggggga ctataccctg tactcaccac cgccgcctgc agggggtgcc attctcagct ttatcctcaa cgtgctaaga gggttcaact tctcaacaga gtctatggcc aggcctgaag ggagggtgaa cgtgtaccac caccttgtag agacgctcaa gtttgccaag gggcagaggt ggaggctggg ggaccctcga agccacccga agctccagaa tgcctcccgg gacctgctgg gggagaccct ggcccagctc atccgccaac agatcgatgg ccggggggac caccagctca gccactacag cttggccgag gcctggggcc acgggacagg cacgtcccat gtgtctgtgc tgggggagga tggcagcgcc gtggctgcca ccagcaccat caacacaccc tttggagcga tggtgtattc accacggaca ggcatcatcc tcaacaacga gctcctggac ttatgcgagc gatgcccccg gggttccggc accaccccct cacctgtgag tggagacagg gtgggtggag ctcccggaag gtgctggccc ccagttccag gcgagcgttc cccatcctcc atggtgccct ccatcttgat caacaaagcc caggggtcga agctagtgat tggcggggct ggcggggagc tcatcatctc tgctgtggcc caggccatca tgagcaagct gtggcttggc tttgacctga gagcggccat tgcagccccc atcctgcatg tcaacagcaa gggctgtgtg gagtacgagc ccaacttcag ccaggaggtg cagaggggac tccaagaccg tggccagaac cagacccaga ggcccttctt cctgaacgtg gtccaggctg tgtcccagga gggggcctgt gtgtacgccg tctcggacct gaggaagagt ggggaggccg caggctacta Protein function: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 (PubMed:21447318). Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine (PubMed:21447318). May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318). Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656). [The UniProt Consortium]