FAM35A (Vector pUC, Accession No. BC051863)

Length: 2508 Sequence: atgagtggag gatctcaagt ccacattttt tggggtgctc caattgctcc actgaaaatc acagtatcag aagacacagc ttctttaatg tctgttgctg acccctggaa aaaaattcag cttttataca gtcaacattc tttatatctg aaggatgaaa aacagcacaa aaatcttgaa aactataaag tcccagaatc tattggttct ccagatctta gtggtcattt cttagcaaac tgtatgaata gacatgttca tgtgaaagat gactttgtac gttctgtttc tgaaacacag aatatagaat cccagaagat tcactcctct agactgagtg atataactag ctctaatatg caaatatgtg gatttaaaag cacagttccg catttcaccg aagaagaaaa gtatcaaaag cttctcagtg aaaataaaat tagagatgaa cagcctaaac atcagccaga tatatgtggt aagaacttta acacaaattt gtttcagttg ggccataaat gtgcagctgt gttggatttg gtttgtagta ctgaaaaaat taatataggg cctgaagtgg tacaaagaga gtgtgtgcca acagaatatc atgaaataca aaaccagtgt ttgggattat tttcctcgaa cgcagtagat aagtcaaggt ctgaagcagc agttaggaag gtctcagacc ttaaaatatc aactgataca gaatttctca gtataattac ctccagccag gttgcttttt tagctcaaaa gaaagataaa aggcggagtc ctgtaaataa agggaatgta aacatggaga ctgaaccaaa ggcaagttac ggggagataa gaatacctga agagaattcg attcagcttg atggttttac agaagcatat gaaagtggac aaaaccaagc atattccctt gaacttttta gtcctgtttg tcctaaaaca gaaaatagcc gcattcacat aaactctgat aaaggtcttg aagaacatac aggatctcaa gaacttttca gttctgaaga tgaactgcca ccaaatgaga tacgtattga gttgtgtagc tcaggaatac tgtgttccca actaaatacc ttccacaaaa gtgctattaa aagaagctgt acctctgaag ataaagtggg ccagtctgaa gctctatcta gagtccttca agtagctaag aaaatgaagt tgatttctaa tggaggagat tctgctgtag aaatggatcg gagaaatgtg tctgaattta agagtattaa aaaaacatca ttaataaaaa actgtgattc taaaagccag aagtataatt gtttagtcat ggtgctatct ccatgccatg tgaaggaaat aaacataaaa ttcggaccaa attctggctc taaagtgcct ttagcaacag ttacagtaat tgatcaatca gaaactaaga agaaggtttt tctgtggagg actgcagcat tttgggcatt tacagtgttt cttggagata taattttact cacagatgtt gttattcatg aggaccaatg gattggcgag acagtactac aatcaacatt tagcagtcag ttattaaatc ttgggagtta ttcatctatt cagcctgaag aatattccag tgtagttagt gaagttgtac ttcaagactt actggcatat gtgtcctcaa aacattccta cctcagagat cttcctccga ggcagcctca gagggtgaac agtatagact ttgtagaatt ggagcacctt caacctgatg tattagtcca cgcagtacta agagttgttg atttcactat actgacagag gcagtataca gttatagagg acagaagcag aaaaaagtta tgttaacagt ggaacaggcc caagatcaac attatgcgct tgtattatgg ggtcctggag cagcctggta ccctcaactt caaaggaaaa aaggagtggt tctgattaaa gcccagattt cagagctggc atttcctatt acagcatctc agaagatagc gctaaatgct cacagttctc tgaagagtat tttttcttct cttcccaaca tcgtatatac tggttgtgca aaatgtggat tggaactaga aacagatgag aacaggatct acaaacaatg ttttagctgc ttgccattta ctatgaagaa aatatattat aggccagcgt taatgactgc cattgatgga agacatgatg tttgtatccg tgtagaatca aagctgatag agaagattct tctcaacatt tctgcagact gcctcaacag agtgatagtt ccttcctcag agatcaccta tgggatggtc gtggcagacc tgttccactc cttgttggca gtcagcgcag aaccttgtgt attaaagatt cagagccttt ttgtgttaga tgaaaacagc tatccattac aacaagattt ctccctcctg gatttttatc ctgacattgt aaagcatgga gccaatgccc Protein function: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). [The UniProt Consortium]