EXOSC3 (Vector pUC, Accession No. BC002437)

Length: 828 Sequence: atggccgaac ctgcgtctgt cgcggctgaa tctctcgcgg gcagcagggc gcgcgctgca cgcacagtac taggtcaggt ggtgctcccg ggtgaggagc tgctcctgcc ggaacaggag gacgcggaag gccctggggg tgcagtggag cgaccgttga gcctgaatgc tagagcgtgc tcgcgggtgc gcgttgtatg cggtccgggc cttcggcgct gtggggaccg cctgctggtc accaagtgcg gccgcctccg tcacaaggag cccggcagtg gcagcggcgg cggtgtttac tgggtggact ctcagcagaa gcggtatgtt ccagtaaaag gagaccatgt gattggcata gtgacagcta aatctggaga tatattcaaa gttgatgttg gagggagtga gccagcttct ttgtcttact tgtcatttga aggtgcaact aaaagaaaca gaccaaatgt gcaggttgga gatctcatct atggccaatt tgtggttgct aataaagaca tggaaccaga gatggtctgt attgacagct gtggacgagc caatggaatg ggtgtcattg gacaggatgg tctgcttttt aaagtgactc tgggcttaat tagaaagcta ttagctccag attgtgaaat catacaggaa gtgggaaaac tctatccact ggagatagta tttggaatga atggaagaat atgggttaag gcaaaaacca tccagcagac tttaattttg gcaaacattt tagaagcttg tgaacacatg acgtcagatc aaagaaaaca gatcttctcc agattggcag Protein function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5. [The UniProt Consortium]