DTX3 (Vector pUC, Accession No. BC114498)

Length: 1044 Sequence: ATGTCGTTCG TCCTGTCCAG AATGGCAGCC TGTGGAGGCA CCTGCAAGAA CAAAGTGACT GTGTCCAAGC CCGTGTGGGA CTTCCTGAGC AAAGAGACCC CAGCCCGGCT GGCCCGGCTT CGGGAGGAGC ACCGTGTGTC CATCCTCATA GATGGCGAGA CTTCTGACAT CTATGTTCTC CAGCTTTCCC CACAGGGTCC TCCCCCGGCC CCTCCAAATG GGCTCTACCT AGCCCGGAAG GCTCTCAAGG GGCTGCTAAA AGAGGCAGAG AAAGAGCTGA AGAAAGCTCA GAGGCAGGGG GAGCTGATGG GCTGCCTGGC TCTGGGGGGT GGAGGGGAGC ACCCTGAGAT GCACCGCGCA GGCCCACCCC CTCTCCGAGC AGCCCCACTT CTGCCCCCAG GAGCTCGGGG GCTCCCCCCT CCTCCTCCCC CCCTGCCCCC ACCTCTTCCT CCTCGCCTTC GGGAGGAGGC AGAAGAGCAG GAGAGCACCT GCCCCATCTG TCTGGGGGAG ATCCAGAATG CCAAGACATT GGAGAAGTGC CGGCATTCAT TCTGCGAGGG CTGCATCACC CGGGCTCTGC AGGTGAAAAA GGCCTGCCCC ATGTGCGGCC GCTTCTATGG GCAGCTGGTG GGCAACCAGC CCCAGAATGG GCGGATGCTG GTCTCTAAGG ACGCCACCCT CCTACTGCCC AGCTATGAGA AGTACGGCAC CATTGTCATC CAGTACGTCT TCCCGCCCGG TGTCCAGGGG GCTGAACACC CAAACCCAGG AGTTCGGTAT CCTGGCACCA CACGGGTGGC CTACCTCCCG GACTGCCCTG AGGGCAACAA GGTGCTGACC CTGTTCCGCA AGGCGTTTGA CCAGCGTCTC ACCTTCACTA TCGGCACGTC CATGACCACA GGGAGACCGA ATGTCATCAC CTGGAACGAC ATCCACCACA AGACCAGCTG CACAGGGGGA CCCCAGCTGT TTGGGTACCC AGACCCCACC TACCTGACCC GGGTGCAAGA GGAGCTGAGA GCGAAGGGTA TCACAGATGA Protein function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. [The UniProt Consortium]