DOCK5 (Vector pENTR223.1, Accession No. BC011877)

Length: 1053 Sequence: atggcccgct ggatcccgac caagaggcag aagtacgggg ttgcgatcta taactacaat gcttctcaag atgtggagct ctccttgcag atcggtgaca cagttcacat cctggagatg tacgagggtt ggtacagagg atataccctc caaaataaat ctaaaaaggg cattttccct gaaacatata tccatttgaa agaggcaact gtggaagacc tggggcagca tgaaaccgtg attcctggcg agctccccct ggtgcaggag ctcacgtcca ctctgcgaga atgggctgtc atctggcgaa agctctacgt gaacaacaag ctcaccctct tccgccagct gcagcagatg acgtacagcc tgatcgagtg gcggtcccag atcctgtctg ggacgctccc caaggatgaa ctggcagagc tcaagaagaa agtcacagcc aaaattgatc atgggaacag aatgctgggg ttagatctgg tggtgcgaga tgacaatggg aacatcctag accctgacga aaccagcacc attgccctct tcaaggccca tgaggtggcc tccaaaagga ttgaggaaaa gatccaagaa gagaagtcaa tcctgcagaa cctcgatttg cggggccagt ccatcttcag taccatccac acctatggcc tctatgtgaa cttcaagaac tttgtctgca acatcgggga agatgcagag ttgtttatgg ccctctacga cccagaccag tccactttta tcagtgagaa ctatctaatt cgttggggca gtaacgggat gcccaaggaa atagagaagc tcaataacct ccaagcagtg tttacagacc ttagcagcat ggacctcatc cggccccgcg tcagccttgt atgccagatt gtccgcgtgg gccatatgga gctgaaggaa ggcaagaagc acacctgtgg actccgaaga ccttttggag tggcagtgat ggatattact gatatcatac atgggaaggt ggatgatgaa gaaaagcagc attttattcc ctttcagcag Protein function: Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). [The UniProt Consortium]