DNAJC3 (Vector pENTR223.1, Accession No. BC033823)

Length: 705 Sequence: atggtggccc ccggctccgt gaccagccgg ctgggctcgg tattcccctt cctgctagtc ctggtggatc tgcagtacga aggtgctgaa tgtggagtaa atgcagatgt tgagaaacat cttgaattgg gcaagaaatt acttgcagct ggacagctag ctgatgcttt atctcagttt catgctgccg tagatggtga ccctgataac tatattgctt attatcggag ggctactgtc tttttagcta tgggcaaatc aaaagctgca cttcctgatt taactaaagt gattcaattg aagatggact tcactgcagc aagattacag agaggtcact tattactcaa acaaggaaaa cttgatgaag cagaagatga ttttaaaaaa gtggtgtttc ctgttccttc tctgttggga ctccagcgtt ctctcctaga tgatctatac ttgctatttt ggttcttcct tatgaagaag gtgactttca gatgcctctc gtcagccatc tctgaatgcc ttcctcagtc tttaaatttg atgaagttca atttgttgat ttccttttta cttctgtgga ctgtgcgttt ggtgtcatgt ctaagaagta ttcactacgc cgtaggatct aaaacttttc tcatatcttc taaaagtttt atggttttgt gttttatttt taagcccata gtctatttga Protein function: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. [The UniProt Consortium]