CHTF18 (Vector pUC, Accession No. BC006278)

Length: 2928 Sequence: atggaggact acgagcagga gctgtgcggc gtcgaggatg atttccacaa ccagttcgcg gccgagctgg aggtgctggc agagctggaa ggggcgtcga ctccgtcgcc ctccggggtc cccctgttca ccgcgggccg acccccgcgg acgttcgagg aggcccttgc cagaggggac gcggcctcca gtcccgcccc agccgcatct gtgggcagca gccagggcgg cgccaggaag aggccggtgg acgccgacct gcagccggcc gggtccctgc cccacgcccc caggatcaaa cggcctaggc tgcaggtggt caagaggctg aacttcaggt cggaggagat ggaggagccg ccccctcccg actcctcgcc gacggacatc accccgccgc cgagccctga ggacctcgca gagctttggg gccacggagt ctcagaagct gctgccgacg tgggtctcac acgggcctca ccagctgccc gcaatcccgt cctgaggcgg ccccccatct tggaggacta cgtccacgtg acatccacgg agggcgtccg ggcttatctg gtgctgcgtg ctgaccccat ggccccgggg gtgcagggct ctctcctcca cgtcccatgg cgaggcggtg gccagctgga cctgctgggt gtgtccttag cctccctgaa gaagcaggtc gacggcgagc ggcgggagcg gctgcttcag gaggcccaga ggctttcaga caccctgcac agtctcaggt cgggggagga ggaggcagcc cagcccttgg gggcccctga ggaggagccg actgacggtc aagacgcctc cagtcactgc ctctgggtgg atgagtttgc accgcgccac tacacggagc tgctcagtga tgacttcacc aaccgctgcc tgctcaagtg gctgaagttg tgggacctgg tggtgtttgg ccacgagagg ccttcccgga agcccaggcc cagtgttgag ccggcccggg tcagcaagga ggccacagcc ccaggcaagt ggaagagcca cgaacaggtg ctggaggaga tgctggaggc tgggctggac ccgagccagc gaccgaagca gaaggtggca ctgctctgtg ggcccccggg gctggggaag accaccctgg cacacgtgat tgcgcgtcac gcggggtact ctgtggtgga gatgaacgcc agtgacgacc gtagcccgga ggtcttccgc acacgcatcg aggcggccac ccagatggag tcggtgctgg gtgctggcgg gaagcccaac tgcctggtca tcgatgagat cgacggggcc cccgtggccg ccatcaatgt cctcctgagc atcctgaacc gcaaggggcc acaggaggtg gggccacagg gcccggctgt gccttcggga ggcggccgac ggcgccgggc agaggggggg ctcctcatga ggcccattat ctgcatttgc aatgaccagt tcgcaccgtc cctgcggcag ctgaagcagc aggccttcct gctccacttc ccgccgactc tgccctcgag gctggtgcag cggctccagg aggtctccct gcggcagggc atgagggccg acccaggggt gctggccgcc ctctgtgaga aaactgacaa tgacatccgg gcctgcatca acaccctgca gttcctgtac agccggggcc agcgggagct gagcgtgcgg gacgtgcagg ccacacgcgt gggcctcaag gaccagcgca gagggctctt ctcggtgtgg caggaggtct tccagctgcc tcgagcccag aggcgccgtg tgggccagga ccccgccctg cctgctgaca cactcctgct gggtgacggg gacgcgggct ccctcacctc cgcctcacag cgattctacc gtgtcctgca tgccgctgcc tctgcgggcg agcacgagaa ggtggtccag ggcttgtttg acaacttcct gcgtctgcgg ctgcgagact ccagcctggg tgctgtgtgt gtggccctcg actggctggc cttcgatgac ctgctggcgg gggctgctca tcacagtcag agcttccagc tgctgcgcta cccacccttc ctgcccgtgg ccttccatgt gctgtttgct tccagccaca cacccaggat caccttcccc agcagccagc aggaggccca gaaccggatg agccagatga ggaacctgat ccagacgctg gtgtccggca tcgcgccagc cacgcgcagc cgggccacgc cccaggccct gctcctcgat gccctctgcc tgctcctgga cattcttgca cccaagctcc gccccgtgag cacacagctg tacagcaccc gtgaaaagca acagctggcc agcctggtgg gcacgatgct cgcttacagc ctgacctacc gccaggagcg cacgcccgat ggccagtaca tctacaggct ggagccgaac gtggaggaac tctgccgctt ccctgagctg cctgcccgca agcccctcac ctaccagacg aagcagctca tcgcccgcga gatcgaggtg gagaagatgc ggcgggcgga ggcttctgcc cgggtagaga acagccccca ggtggatggg agccccccag ggctcgaggg tctgctgggg ggcattgggg agaaaggggt gcaccgacct gccccacgca accatgagca gcggctggag cacatcatga ggcgagcggc ccgggaggaa cagcctgaga aggacttctt tggacgtgtg gtcgtcagga gcacagcagt cctgagtgca ggggacacgg ccccggagca ggactcagtg gagcggcgca tgggcacagc ggtgggcagg agcgaggtct ggttccgctt caacgagggt gtctccaacg ccgtgcggcg cagcctgtac atcagggact Protein function: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP- dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). [The UniProt Consortium]