CHST14 (Vector pUC, Accession No. BC049214)

Length: 1131 Sequence: atgttccccc gcccgctgac cccgctggcg gccccaaatg gcgccgagcc cctgggccgg gcgctgaggc gggcccctct gggcagggcc cgggcggggc tgggtgggcc gcccctgctg ctgccgtcca tgctgatgtt tgcggtgatc gtggcctcca gcgggctgct gctcatgatc gagcggggca tcctggccga gatgaagccc ctgcccctgc acccgcccgg ccgcgagggc acagcctggc gcgggaaagc ccccaagcct gggggcctgt ccctcagggc tggggacgcg gacttgcaag tgcggcagga cgtccggaac aggaccctgc gggcggtgtg cggacagcca ggcatgcccc gggacccctg ggacttgccg gtggggcagc ggcgcaccct gctgcgccac atcctcgtaa gtgaccgtta ccgcttcctc tactgctacg tccccaaggt ggcctgctct aactggaagc gggtgatgaa ggtgctggca ggcgtcctgg acagcgtgga cgtccgcctc aagatggacc accgcagtga cctggtgttc ctggccgacc tgcggcctga ggagattcgc taccgcctgc agcactactt taagttcctg tttgtgcggg agcccttgga acgcctcctc tctgcctacc gcaacaagtt tggcgagatc cgagagtacc agcaacgcta tggggctgag atagtgaggc ggtacagggc tggagcgggg cccagccctg caggcgacga tgtcacattc cccgagttcc tgagatacct ggtggatgag gaccctgagc gcatgaatga gcattggatg cccgtgtacc acctgtgcca gccttgtgcc gtgcactatg actttgtggg ctcctatgag aggctggagg ctgatgcaaa tcaggtgctg gagtgggtac gggcaccacc tcacgtccga tttccagctc gccaggcctg gtaccggcca gccagccccg aaagcctgca ttaccacttg tgcagtgccc cccgggccct gctgcaggat gtgctgccta agtatatcct ggacttctcc ctctttgcct acccactgcc taatgtcacc aaggaggcgt gtcagcagtg Protein function: Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development. [The UniProt Consortium]