CABLES1 (Vector pUC, Accession No. BC037218)

Length: 1107 Sequence: atgctttcta agaggggctg ccatgcaaga atatatgctg attttcccat acggcgcctc atctcccaga gatcttcctt ggagaccctg gaagatattg aggagaacgc ccctctccgg agatgtcgaa ctctctcagg ttcacccaga ccaaagaatt ttaagaagat tcattttatc aagaacatgc ggcaacacga taccaggaat ggcagaatag tccttatcag tggcagaaga tccttctgta gtatattttc agtgctgccg tatcgcgaca gtacccaagt cggggacttg aagttggacg gaggaagaca atcaactggt gcagtgagtt tgaaagagat cattggtctg gaaggtgtgg agctgggtgc tgatgggaag actgtttcct atacccaatt tctgttaccc acaaatgcct ttggagcccg gagaaatacc atagactcca cctcctcttt ctcccagttc cgtaacctga gccaccgcag cctctccata ggccgggcaa gcggcaccca ggggagcctc gacacaggta gtgacctggg agactttatg gactatgacc caaatctctt ggatgacccc cagtggcctt gtggcaaaca caaacgcgtt ctgatcttcc cttcctacat gacaacagtg attgactacg tgaagccctc ggatctcaag aaggacatga acgagacctt caaggagaag tttcctcaca ttaagctgac actcagcaaa attaggagtc tgaaacgaga gatgcggaag cttgcgcagg aggactgtgg ccttgaggag cccacggtgg ccatggcctt cgtctacttt gaaaagctcg ccctcaaggg gaaactcaac aaacagaacc ggaagctgtg tgctggggca tgtgtgctgt tagcagccaa aattggaagt gacctcaaaa aacacgaagt caagcattta attgacaaac tggaagagaa gttccggctg aacaggcgag aactgattgc ctttgaattc ccggtgttag tggccttgga attcgccctc cacttgcccg agcacgaagt catgccccac tacagacggc tggtccagag Protein function: Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death. [The UniProt Consortium]