BSCL2 (Vector pENTR223.1, Accession No. BC009866)

Length: 1395 Sequence: atgtctacag aaaaggtaga ccaaaaggag gaagctgggg aaaaagaggt gtgcggagac cagatcaaag gaccggacaa agaggaggaa ccaccagctg ctgcatccca tggccagggg tggcgtccag gtggcagagc agctaggaac gcaaggcctg aacctggggc cagacaccct gctctcccgg ccatggtcaa cgaccctcca gtacctgcct tactgtgggc ccaggaggtg ggccaagtct tggcaggccg tgcccgcagg ctgctgctgc agtttggggt gctcttctgc accatcctcc ttttgctctg ggtgtctgtc ttcctctatg gctccttcta ctattcctat atgccgacag tcagccacct cagccctgtg catttctact acaggaccga ctgtgattcc tccaccacct cactctgctc cttccctgtt gccaatgtct cgctgactaa gggtggacgt gatcgggtgc tgatgtatgg acagccgtat cgtgttacct tagagcttga gctgccagag tcccctgtga atcaagattt gggcatgttc ttggtcacca tttcctgcta caccagaggt ggccgaatca tctccacttc ttcgcgttcg gtgatgctgc attaccgctc agacctgctc cagatgctgg acacactggt cttctctagc ctcctgctat ttggctttgc agagcagaag cagctgctgg aggtggaact ctacgcagac tatagagaga actcgtacgt gccgaccact ggagcgatca ttgagatcca cagcaagcgc atccagctgt atggagccta cctccgcatc cacgcgcact tcactgggct cagatacctg ctatacaact tcccgatgac ctgcgccttc ataggtgttg ccagcaactt caccttcctc agcgtcatcg tgctcttcag ctacatgcag tgggtgtggg ggggcatctg gccccgacac cgcttctctt tgcaggttaa catccgaaaa agagacaatt cccggaagga agtccaacga aggatctctg ctcatcagcc aggtgcaggg cctgaaggcc aggaggagtc aactccgcaa tcagatgtta cagaggatgg tgagagccct gaagatccct cagggacaga gggtcagctg tccgaggagg agaaaccaga tcagcagccc ctgagcggag aagaggagct agagcctgag gccagtgatg gttcaggctc ctgggaagat gcagctttgc tgacggaggc caacctgcct gctcctgctc ctgcttctgc ttctgcccct gtcctagaga ctctgggcag ctctgaacct gctgggggtg ctctccgaca gcgccccacc tgctctagtt Protein function: Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:19278620, PubMed:21533227, PubMed:31708432, PubMed:30293840). In association with TMEM159/LDAF1, defines the sites of LD formation in the ER (PubMed:31708432). Also required for growth and maturation of small nascent LDs into larger mature LDs (PubMed:27564575). Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs (PubMed:31178403, PubMed:27879284). Regulates the maturation of ZFYVE1- positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts (PubMed:30970241). Binds anionic phospholipids including phosphatidic acid (PubMed:30293840). Plays an important role in the differentiation and development of adipocytes. [The UniProt Consortium]