ATP6AP1 (Vector pUC, Accession No. BC000724)

Length: 1413 Sequence: atgatggcgg ccatggcgac ggctcgagtg cggatggggc cgcggtgcgc ccaggcgctc tggcgcatgc cgtggctgcc ggtgtttttg tcgttggcgg cggcggcggc ggcggcagcg gcggagcagc aggtcccgct ggtgctgtgg tcgagtgacc gggacttgtg ggctcctgcg gccgacactc atgaaggcca catcaccagc gacttgcagc tctctaccta cttagatccc gccctggagc tgggtcccag gaatgtgctg ctgttcctgc aggacaagct gagcattgag gatttcacag catatggcgg tgtgtttgga aacaagcagg acagcgcctt ttctaaccta gagaatgccc tggacctggc cccctcctca ctggtgcttc ctgccgtcga ctggtatgca gtcagcactc tgaccactta cctgcaggag aagctcgggg ccagcccctt gcatgtggac ctggccaccc tgcgggagct gaagctcaat gccagcctcc ctgctctgct gctcattcgc ctgccctaca cagccagctc tggtctgatg gcacccaggg aagtcctcac aggcaacgat gaggtcatcg ggcaggtcct gagcacactc aagtccgaag atgtcccata cacagcggcc ctcacagcgg tccgcccttc cagggtggcc cgtgatgtag ccgtggtggc cggagggcta ggtcgccagc tgctacaaaa acagccagta tcacctgtga tccatcctcc tgtgagttac aatgacaccg ctccccggat cctgttctgg gcccaaaact tctctgtggc gtacaaggac cagtgggagg acctgactcc cctcaccttt ggggtgcagg aactcaacct gactggctcc ttctggaatg actcctttgc caggctctca ctgacctatg aacgactctt tggtaccaca gtgacattca agttcattct ggccaaccgc ctctacccag tgtctgcccg gcactggttt accatggagc gcctcgaagt ccacagcaat ggctccgtcg cctacttcaa tgcttcccag gtcacagggc ccagcatcta ctccttccac tgcgagtatg tcagcagcct gagcaagaag ggtagtctcc tcgtggcccg cacgcagccc tctccctggc agatgatgct tcaggacttc cagatccagg ctttcaacgt aatgggggag cagttctcct acgccagcga ctgtgccagc ttcttctccc ccggcatctg gatggggctg ctcacctccc tgttcatgct cttcatcttc acctatggcc tgcacatgat cctcagcctc aagaccatgg atcgctttga tgaccacaag ggccccacta tttctttgac ccagattgtg Protein function: Accessory subunit of the proton-transporting vacuolar (V)- ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). [The UniProt Consortium]