ATP13A2 (Vector pUC, Accession No. BC030267)

Length: 3477 Sequence: atgagcgcag acagcagccc tctcgtgggc agcacgccca ccggttatgg gaccctgacg atagggacat caatagatcc cctcagctcc tcagtttcat ccgtgaggct cagcggctac tgtggcagtc catggagggt catcggctat cacgtcgtgg tctggatgat ggctgggatc cctttgctgc tcttccgttg gaagcccctg tggggggtgc ggctgcggct ccggccctgc aacctggccc acgccgaaac actcgttatc gaaataagag acaaagagga tagttcctgg cagctcttca ctgtccaggt gcagactgag gccatcggcg agggcagcct ggagccgtcc ccacagtccc aggcagagga tggccggagc caggcggcag ttggggcggt accagagggt gcctggaagg atacggccca gctccacaag agcgaggagg cgaagcgggt gctgcggtat tacctcttcc agggccagcg ctatatctgg atcgagaccc agcaagcctt ctaccaggtc agcctcctgg accatggccg ctcttgtgac gacgtccacc gctcccgcca tggcctcagc ctccaggacc aaatggtgag gaaggccatt tacggcccca acgtgatcag cataccggtc aagtcctacc cccagctgct ggtggacgag gcactgaacc cctactatgg gttccaggcc ttcagcatcg cgctgtggct ggctgaccac tactactggt acgccctgtg catcttcctc atttcctcca tctccatctg cctgtcgctg tacaagacca gaaagcaaag ccagactcta agggacatgg tcaagttgtc catgcgggtg tgcgtgtgcc ggccaggggg agaggaagag tgggtggact ccagtgagct agtgcccgga gactgcctgg tgctgccccg ggagggtggg ctgatgccct gtgatgccgc cctggtggcc ggcgagtgca tggtgaatga gagctctctg acaggagaga gcattccagt gctgaagacg gcactgccgg aggggctggg gccctactgt gcagagacac accggcggca cacactcttc tgcgggaccc tcatcttgca ggcccgggcc tatgtgggac cgcacgtcct ggcagtggtg acccgcacag ggttctgcac ggcaaaaggg ggcctggtga gctccatctt gcacccccgg cccatcaact tcaagttcta taaacacagc atgaagtttg tggctgccct ctctgtcctg gctctcctcg gcaccatcta cagcatcttc atcctctacc gaaaccgggt gcctctgaac gagattgtaa tccgggctct cgacctggtg accgtggtgg tgccacctgc cctgcctgct gccatgactg tgtgcacgct ctacgcccag agccgactgc ggagacaggg cattttctgc atccacccac tgcgcatcaa cctggggggc aagctgcagc tggtgtgttt cgacaagacg ggcaccctca ctgaggacgg cttagacgtg atgggggtgg tgcccctgaa ggggcaggca ttcctgcccc tggtcccaga gcctcgccgc ctgcctgtgg ggcccctgct ccgagcactg gccacctgcc atgccctcag ccggctccag gacacccccg tgggcgaccc catggacttg aagatggtgg agtctactgg ctgggtcctg gaggaagagc cggctgcaga ctcagcattt gggacccagg tcttggcagt gatgagaccc ccactttggg agccccagct gcaggcaatg gaggagcccc cggtgccagt cagcgtcctc caccgcttcc ccttctcttc ggctctgcag cgcatgagtg tggtggtggc gtggccaggg gccactcagc ccgaggccta cgtcaaaggc tccccggagc tggtggcagg gctctgcaac cccgagacag tgcccaccga cttcgcccag atgctgcaga gctatacagc tgctggctac cgtgtcgtgg ccctggccag caagccactg cccactgtgc ccagcctgga ggcagcccag caactgacga gggacactgt ggaaggagac ctgagcctct tggggctgct ggtcatgagg aacctactga agccgcagac aacgccagtt atccaggctc tgcgaaggac ccgcatccgc gccgtcatgg tgacagggga caacctgcag acagcggtga ctgtggcccg gggctgtggc atggtggccc cccaggagca tctgatcatc gtccacgcca cccaccctga gcggggtcag cctgcctctc tcgagttcct gccgatggag tcccccacag ccgtgaatgg cgttaaggtc ctggtccagg gcactgtctt tgcccgcatg gcccctgagc agaagacaga gctggtgtgc gagctacaga agcttcagta ctgcgtgggc atgtgcggag acggcgccaa tgactgtggg gccctgaagg cggctgatgt cggcatctcg ctgtcccagg cagaagcctc agtggtctca cccttcacct cgagcatggc cagtattgag tgcgtgccca tggtcatcag ggaggggcgc tgttcccttg acacttcatt cagcgtcttc aagtacatgg ctctgtacag cctgacccag ttcatctccg tcctgatcct ctacacgatc aacaccaacc tgggtgacct gcagttcctg gccatcgacc tggtcatcac caccacagtg gcagtgctca tgagccgcac ggggccagcg ctggtcctgg gacgggtgcg gccaccgggg gcgctgctca gcgtgcccgt gctcagcagc ctgctgctgc agatggtcct ggtgaccggc gtgcagctag ggggctactt cctgaccctg gcccagccat ggttcgtgcc tctgaacagg acagtggccg caccagacaa cctgcccaac tacgagaaca ccgtggtctt ctctctgtcc agcttccagt acctcatcct ggctgcagcc gtgtccaagg gggcgccctt ccgccggccg ctctacacca atgagcgtgc tagaccagtg cctccccgcc tgcctgcgcc gcctccggcc caagcgggcc tccaagaagc gcttcaagca gctggaacga gagctggccg agcagccctg gccgccgctg cccgccggcc ccctgaggta gtgcaggccc acgggcaccc cagacactgg aactccctgc ctctgagcca ccaactggac ccctctccag caacaccacc gccaccacct cccacatccc tgaggttggc gactgtctac actcctcccc cgagaccacc cccaccctgg ggaagcgttg actactgtcc cctaccttgg accatcccgc gtaggggtgg cagcccccag ctcccctcag tgctgctgtc Protein function: ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine (PubMed:31996848). Also stimulates cellular uptake of polyamines and protects against polyamine toxicity (PubMed:31996848). Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024). Contributes to cellular zinc homeostasis (PubMed:24603074). Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress (PubMed:26134396). Required for proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957). Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels (PubMed:27278822). Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Promotes secretion of exosomes as well as secretion of SCNA via exosomes (PubMed:25392495, PubMed:24603074). Plays a role in lipid homeostasis (PubMed:31132336). [The UniProt Consortium]