YSK05

YSK05 is an ionizable cationic amino lipid (apparent pKa = ~6.5) that has been used in combination with other lipids in the formation of liposomes and lipid nanoparticles (LNPs). Administration of cyclic di-GMP (Cay-17144) in YSK05-containing liposomes increases serum levels of IFN-beta, IFN-gamma, IL-6, and TNF-alpha and activates natural killer (NK) cells in mice, as well as decreases lung metastasis in a B16/F10 murine melanoma model of metastasis. Intravenous administration of factor VII siRNA in YSK05-containing LNPs reduces factor VII activity in isolated mouse plasma.Formal Name: 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-piperidine. CAS Number: 1318793-78-0. Molecular Formula: C42H77NO2. Formula Weight: 628.1. Purity: >90%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 25 mg/ml. SMILES: CCCCC/C=C\C/C=C\CCCCCCCCOC1(CCN(CC1)C)OCCCCCCCC/C=C\C/C=C\CCCCC. InChi Code: InChI=1S/C42H77NO2/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-40-44-42(36-38-43(3)39-37-42)45-41-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2/h12-15,18-21H,4-11,16-17,22-41H2,1-3H3/b14-12-,15-13-,20-18-,21-19-. InChi Key: KURBRAZBXURPCJ-QYCRHRGJSA-N.