YK-009

YK-009 is an ionizable cationic lipid (pKa = 6.512) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Administration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant mRNA in YK-009-containing LNPs induces the production of IgG that binds to the SARS-CoV-2 receptor-binding domain (RBD) in mice, with a boost in IgG titers 10 days after a second dose.Formal Name: 6-[[4-(decyloxy)-4-oxobutyl](2-hydroxyethyl)amino]-hexanoic acid, 2-octyldecyl ester. CAS Number: 2761458-86-8. Molecular Formula: C40H79NO5. Formula Weight: 654.1. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 5 mg/ml. SMILES: OCCN(CCCCCC(OCC(CCCCCCCC)CCCCCCCC)=O)CCCC(OCCCCCCCCCC)=O. InChi Code: InChI=1S/C40H79NO5/c1-4-7-10-13-16-17-20-26-36-45-39(43)31-27-33-41(34-35-42)32-25-21-24-30-40(44)46-37-38(28-22-18-14-11-8-5-2)29-23-19-15-12-9-6-3/h38,42H,4-37H2,1-3H3. InChi Key: QXJDKBITLMHUSD-UHFFFAOYSA-N.