YHS-12

YHS-12 is an ionizable cationic lipid (pKa = 6.506) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo. LNPs containing YHS-12 and the macrophage targeting peptide CRVLRSGSC and encapsulating mRNA encoding chimeric antigen receptor targeting methicillin-resistant S. aureus (MRSA) and siRNA targeting caspase-11 increase the phagocytosis rate of MRSA in RAW 264.7 macrophages and primary mouse bone marrow-derived macrophages (BMDMs). Intravenous administration of these LNPs decreases blood bacterial burden and increases survival in a model of sepsis using cyclophosphamide-induced immunosuppressed mice.Formal Name: (2E)-N1,N4-bis[2-(didodecylamino)ethyl]-2-butenediamide. CAS Number: 2959463-68-2. Molecular Formula: C56H112N4O2. Formula Weight: 873.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Sparingly Soluble: 1-10 mg/ml, Methanol: Slightly Soluble: 0.1-1 mg/ml. SMILES: CCCCCCCCCCCCN(CCNC(/C=C/C(NCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)=O)CCCCCCCCCCCC. InChi Code: InChI=1S/C56H112N4O2/c1-5-9-13-17-21-25-29-33-37-41-49-59(50-42-38-34-30-26-22-18-14-10-6-2)53-47-57-55(61)45-46-56(62)58-48-54-60(51-43-39-35-31-27-23-19-15-11-7-3)52-44-40-36-32-28-24-20-16-12-8-4/h45-46H,5-44,47-54H2,1-4H3,(H,57,61)(H,58,62)/b46-45+. InChi Key: PHYKVTFJFHNIHG-XVIFHXHVSA-N.