Valilactone

Valilactone is an esterase inhibitor produced by a cultured strain of soil actinomycetes. It is reported to inhibit hog liver esterase and hog pancreas lipase with IC50 values of 29 and 0.14 ng/ml, respectively. Valilactone can also inhibit fatty acid synthase with an IC50 value of 0.30 µM and demonstrates selective toxicity towards MDA-MB-231 breast cancer cells with an IC50 value of 10.5 µM.Formal Name: N-formyl-L-valine, (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]hexyl ester. CAS Number: 113276-96-3. Synonyms: (-)-Valilactone. Molecular Formula: C22H39NO5. Formula Weight: 397.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 10 mg/ml. SMILES: CCCCC[C@H](OC([C@@H](NC([H])=O)C(C)C)=O)C[C@H]1[C@H](CCCCCC)C(O1)=O. InChi Code: InChI=1S/C22H39NO5/c1-5-7-9-11-13-18-19(28-21(18)25)14-17(12-10-8-6-2)27-22(26)20(16(3)4)23-15-24/h15-20H,5-14H2,1-4H3,(H,23,24)/t17-,18-,19-,20-/m0/s1. InChi Key: WWGVIIVMPMBQFV-MUGJNUQGSA-N.