Tomatine

Tomatine is a steroidal saponin that has been found in S. lycopersicum and has diverse biological activities. It is active against a panel of 19 plant pathogenic fungi (EC50s = 13-912 µM) and inhibits the growth of L. amazonensis promastigotes (IC50 = 124 nM). Tomatine (0.75, 1, and 1.5 µM) inhibits autophagy and induces apoptosis in SKOV3 ovarian cancer cells. Dietary administration of tomatine (0.1 and 0.2% w/w) decreases serum LDL levels and increases fecal cholesterol secretion in hamsters.Formal Name: (3beta,5alpha,22beta,25S)-spirosolan-3-yl O-beta-D-glucopyranosyl-(1->2)-O-[beta-D-xylopyranosyl-(1->3)]-O-beta-D-glucopyranosyl-(1->4)-beta-D-galactopyranoside. CAS Number: 17406-45-0. Synonyms: Lycopersicin, NSC 9223, NSC 234440, alpha-Tomatine. Molecular Formula: C50H83NO21. Formula Weight: 1034.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 2 mg/ml. SMILES: C[C@H]1CC[C@@]2(O[C@]3(C[C@]4([C@@]5(CC[C@]6(C[C@H](CC[C@@]6([C@]5(CC[C@@]4([C@]3([C@@H]2C)[H])C)[H])C)O[C@@]7(O[C@@H]([C@@H]([C@@H]([C@H]7O)O)O[C@]8([C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O[C@]9([C@@H]([C@H]([C@@H](CO9)O)O)O)[H])O[C@@]%10(O[C@@H]([C@H]([. InChi Code: InChI=1S/C50H83NO21/c1-20-7-12-50(51-15-20)21(2)32-28(72-50)14-26-24-6-5-22-13-23(8-10-48(22,3)25(24)9-11-49(26,32)4)65-45-40(63)37(60)41(31(18-54)68-45)69-47-43(71-46-39(62)36(59)34(57)29(16-52)66-46)42(35(58)30(17-53)67-47)70-44-38(61)33(56)27(55)1. InChi Key: REJLGAUYTKNVJM-SGXCCWNXSA-N. Origin: Plant/Tomato.