tetranor-PGDM

Prostaglandin D2 (PGD2, Cay-12010) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as beta-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine. The levels of tetranor-PGDM and 2,3-dinor-11beta-PGF2alpha (Cay-16530), a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.Formal Name: 9alpha-hydroxy-11,15-dioxo-13,14-dihydro-2,3,4,5-tetranor-prostan-1,20-dioic acid. CAS Number: 70803-91-7. Synonyms: tetranor-PGD Metabolite, tetranor-Prosatglandin D Metabolite. Molecular Formula: C16H24O7. Formula Weight: 328.4. Purity: >90%. Formulation: (Request formulation change), A solution in methanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@@H]1[C@H](CCC(O)=O)[C@@H](CCC(CCCCC(O)=O)=O)C(C1)=O. InChi Code: InChI=1S/C16H24O7/c17-10(3-1-2-4-15(20)21)5-6-11-12(7-8-16(22)23)14(19)9-13(11)18/h11-12,14,19H,1-9H2,(H,20,21)(H,22,23)/t11-,12-,14+/m1/s1. InChi Key: VNJBSPJILLFAIC-BZPMIXESSA-N.