Strophanthidin

Strophanthidin is a cardenolide that has been found in A. schimperi and has diverse biological activities. It is an inhibitor of N-acetyltransferase (IC50 = ~1.2 µM). Strophanthidin (1 µM) reduces maximal Na+/K+-ATPase pump activity and cell attachment and increases cell death in MDCK-C7 cells. It decreases the levels of steroid receptor coactivator 3 (SRC-3) in MCF-7 breast cancer cells when used at a concentration of 500 nM. Strophanthidin (50 µM) increases calcium efflux and sarcoplasmic reticulum calcium levels in a voltage-clamp assay using isolated and perfused guinea pig hearts.Formal Name: 3beta,5beta,14-trihydroxy-19-oxo-card-20(22)-enolide. CAS Number: 66-28-4. Synonyms: NSC 86078. Molecular Formula: C23H32O6. Formula Weight: 404.5. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly soluble, Methanol: Slightly soluble. SMILES: [H][C@]12CC[C@]3(C)[C@H](CC[C@@]3([C@](CC[C@]4(O)C[C@@H](O)CC[C@@]42C=O)1[H])O)C(CO5)=CC5=O. InChi Code: InChI=1S/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3/t15-,16+,17-,18+,20+,21-,22-,23-/m0/s1. InChi Key: ODJLBQGVINUMMR-HZXDTFASSA-N. Origin: Plant/Strophanthus kombe.