Solasonine

Solasonine is a steroidal glycoalkaloid that has been found in S. melongena and has diverse biological activities, including anticancer, antiviral, and antiparasitic properties. It inhibits the growth of HT-29 and HepG2 cells by 68.4 and 79.3%, respectively, when used at a concentration of 10 µg/ml. Solasonine inhibits expression of hepatitis B virus surface antigen (HBsAg) in HepG2 2.2.15 cells (IC50 = 5.9 µM). It decreases survival of blood stream forms and epimastigotes of two T. cruzi strains in a concentration-dependent manner.Formal Name: (3beta,22alpha,25R)-spirosol-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1->2)-O-[beta-D-glucopyranosyl-(1->3)]-beta-D-galactopyranoside. CAS Number: 19121-58-5. Synonyms: alpha-Solasonine, NSC 82149. Molecular Formula: C45H73NO16. Formula Weight: 884.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mg/ml. SMILES: OC[C@H]([C@H](O)[C@H](O[C@]1([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]2O[C@@]3([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)O[C@@]2([H])O[C@H](C4)CC[C@@]5(C)C4=CC[C@]6([H])[C@]5([H])CC[C@@]7(C)[C@@]6([H])C[C@@]8([H])[C@]7([H])[C@H](C)[C@]9(NC[C@H](C)CC9)O8. InChi Code: InChI=1S/C45H73NO16/c1-19-8-13-45(46-16-19)20(2)30-27(62-45)15-26-24-7-6-22-14-23(9-11-43(22,4)25(24)10-12-44(26,30)5)57-42-39(61-40-36(54)34(52)31(49)21(3)56-40)38(33(51)29(18-48)59-42)60-41-37(55)35(53)32(50)28(17-47)58-41/h6,19-21,23-42,46-55H,7-18H2,1-5H3/t19-,20+,21+,23+,24-,25+,26+,27+,28-,29-,30+,31+,32-,33+,34-,35+,36-,37-,38+,39-,40+,41+,42-,43+,44+,45-/m1/s1. InChi Key: QCTMYNGDIBTNSK-XEAAVONHSA-N. Origin: Plant/Solanum nigrum.