Ramatroban

Ramatroban is a dual TP and DP2/CRTH2 receptor antagonist (Kis = 4.5 and 4.3 nM for the human receptors, respectively). It is selective for these receptors over the prostaglandin E2 (PGE2) receptor subtypes EP1 and EP2, as well as the FP and IP receptors, at 1 µM. Ramatroban inhibits contractions induced by U-46619 (Cay-16450) or PGD2 (Cay-12010) in isolated guinea pig tracheal rings (pA2s = 8.7 and 8.6, respectively). It also reduces PGD2-induced migration of isolated human eosinophils when used at concentrations of 1, 10, and 100 nM. Ramatroban (5 mg/kg) inhibits ovalbumin-induced airway eosinophil infiltration and mucus cell hyperplasia in an ovalbumin-sensitized mouse model of asthma. Formulations containing ramatroban have been used in the treatment of allergic rhinitis.Formal Name: 3R-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid. CAS Number: 116649-85-5. Synonyms: Bay u3405. Molecular Formula: C21H21FN2O4S. Formula Weight: 416.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 228, 285 nm. SMILES: O=S(N[C@H](CC1)CC2=C1N(CCC(O)=O)C3=CC=CC=C23)(C4=CC=C(F)C=C4)=O. InChi Code: InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1. InChi Key: LDXDSHIEDAPSSA-OAHLLOKOSA-N.