(R)-alpha-Lipoic Acid

(R)-alpha-Lipoic acid is the naturally occurring enantiomer of lipoic acid, a cyclic disulfide antioxidant. It acts as a cofactor in 2-oxo dehydrogenase complex reactions, where it is reduced to dihydrolipoic acid (DHLA, Cay-16372). (R)-alpha-Lipoic acid (100 mg/kg per day) decreases serum levels of malondialdehyde (MDA) and increases the activity of superoxide dismutase (SOD) and total antioxidative capabilities (T-AOC) in a mouse model of accelerated senescence induced by D-galactose (Cay-20890). It also reduces the escape latency in the Morris water maze compared to both D-galactose and vehicle control groups and rescues decreases in neural progenitor cell proliferation in the hippocampal dentate gyrus.Formal Name: (3R)-1,2-dithiolane-3-pentanoic acid. CAS Number: 1200-22-2. Synonyms: (R)-(+)-Lipoic Acid. Molecular Formula: C8H14O2S2. Formula Weight: 206.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:8): 0.25 mg/ml. lambdamax: 331 nm. SMILES: O=C(CCCC[C@H]1SSCC1)O. InChi Code: InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1. InChi Key: AGBQKNBQESQNJD-SSDOTTSWSA-N.