Q1-SM-102 (iodide)

Q1-SM-102 is a cationic quaternary ammonium lipid derivative of the ionizable cationic lipid SM-102 (Cay-33474) that has been used in the generation of lipid nanoparticles (LNPs) for use in vivo. LNPs containing Q1-SM-102 and SM-102 as a cationic lipid pair (CLP) and encapsulating mRNA encoding a luciferase reporter induce luciferase expression in the lungs and spleen in mice.Formal Name: 8-(heptadecan-9-yloxy)-N-(2-hydroxyethyl)-N-methyl-8-oxo-N-(6-oxo-6-(undecyloxy)hexyl)octan-1-aminium, monoiodide. Synonyms: Q1-CAY10779, Q1-Lipid H, Q1-LNP-102. Molecular Formula: C45H90NO5 . I. Formula Weight: 852.1. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Chloroform: Sparingly Soluble: 1-10 mg/ml. SMILES: OCC[N+](CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)(C)CCCCCC(OCCCCCCCCCCC)=O.[I-]. InChi Code: InChI=1S/C45H90NO5.HI/c1-5-8-11-14-17-18-19-25-33-42-50-44(48)36-30-26-32-39-46(4,40-41-47)38-31-24-20-23-29-37-45(49)51-43(34-27-21-15-12-9-6-2)35-28-22-16-13-10-7-3,/h43,47H,5-42H2,1-4H3,1H/q+1,/p-1. InChi Key: OFVAGWVUQMTSAD-UHFFFAOYSA-M.