PPOH

Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, omega-1 and omega-hydroxylated compounds via what is known as the epoxidase pathway. PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes. PPOH inhibits the formation of arachidonate 11,12 epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 of 9 µM, but has effect on the formation of 20-HETE, the omega-hydroxylation product of CYP4A1.Formal Name: 2-(2-propynyloxy)-benzenehexanoic acid. CAS Number: 206052-01-9. Molecular Formula: C15H18O3. Formula Weight: 246.3. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 100 mg/ml, DMSO: 50 mg/ml, Ethanol: 100 mg/ml, Ethanol:PBS (pH 7.2) (1:4): .05 mg/ml, PBS (pH 7.2): 0.5 mg/ml. SMILES: C#CCOC1=CC=CC=C1CCCCCC(O)=O. InChi Code: InChI=1S/C15H18O3/c1-2-12-18-14-10-7-6-9-13(14)8-4-3-5-11-15(16)17/h1,6-7,9-10H,3-5,8,11-12H2,(H,16,17). InChi Key: CUNYTKVXYZYERK-UHFFFAOYSA-N.