Pinane Thromboxane A2

Pinane thromboxane A2 (PTA2) is a stable analog of TXA2. It is a TP receptor antagonist and an inhibitor of thromboxane synthase. PTA2 inhibits U-46619-induced cat coronary artery constriction (ID50 = 0.1 µM), U-46619-induced aggregation of human platelets (IC50 = 2 µM), and rabbit platelet thromboxane synthase (ID50 = 50 µM). PTA2 does not affect PGI synthase up to a concentration of 100 µM.Formal Name: (5Z)-7-[(1S,2R,3R,5S)-3-[(1E,3S)-3-hydroxy-1-octen-1-yl]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-5-heptenoic acid. CAS Number: 71111-01-8. Synonyms: 15(S)-Pinane Thromboxane A2, Pinane TXA2, PTA2. Molecular Formula: C24H40O3. Formula Weight: 376.6. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: >50 mg/ml, DMSO: >25 mg/ml, Ethanol: >100 mg/ml, PBS pH 7.2: >100 µg/ml. SMILES: CCCCC[C@H](O)/C=C/[C@H]1C[C@H]2C[C@H](C2(C)C)[C@@H]1C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C24H40O3/c1-4-5-8-11-20(25)15-14-18-16-19-17-22(24(19,2)3)21(18)12-9-6-7-10-13-23(26)27/h6,9,14-15,18-22,25H,4-5,7-8,10-13,16-17H2,1-3H3,(H,26,27)/b9-6-,15-14+/t18-,19-,20-,21+,22-/m0/s1. InChi Key: OHJIHGVLRDHSDV-BNAVIEMTSA-N.