Pimprinine

Pimprinine is an alkaloid originally isolated from Streptomyces that has diverse biological activities, including anticonvulsant, antiplatelet, and antimicrobial properties. It inhibits deamination of serotonin (5-HT, Cay-14332) by monoamine oxidase (MAO, IC50 = 48 µM). Pimprinine (80 mg/kg) increases the minimum and maximum electroshock seizure thresholds in mice. In a mouse model of tremorine-induced tremors, it increases the latency to tremor onset, as well as reduces the intensity and duration of tremors and the analgesic activity of tremorine when administered at a dose of 80 mg/kg. Pimprinine inhibits aggregation of rabbit platelets induced by arachidonic acid (Cay-90010, Cay-10006607) or collagen (IC50s = 3 and 25 µg/ml, respectively) and arachidonic acid-induced thromboxane A2 (TXA2) synthesis in rabbit platelets in vitro (IC50 = 6 µg/ml). It also inhibits the growth of M. tuberculosis, P. varioti, C. albicans, and S. lutea in vitro (MICs = 25, 1, 1.5, and 2.5 µg/ml, respectively).Formal Name: 3-(2-methyl-5-oxazolyl)-1H-indole. CAS Number: 13640-26-1. Synonyms: NSC 80793. Molecular Formula: C12H10N2O. Formula Weight: 198.2. Purity: >95%. Formulation: (Request formulation change), A powder. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: CC(O1)=NC=C1C2=CNC3=CC=CC=C32. InChi Code: InChI=1S/C12H10N2O/c1-8-13-7-12(15-8)10-6-14-11-5-3-2-4-9(10)11/h2-7,14H,1H3. InChi Key: WZJPGCHCOHYLMB-UHFFFAOYSA-N. Origin: Bacterium/Streptomyces sp..