PEG(2000)-C-DMG

PEG(2000)-C-DMG is a PEGylated derivative of 1,2-dimyristoyl-sn-glycerol (1,2-DMG, Cay-15077). It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA. LNPs containing PEG(2000)-C-DMG and encapsulating siRNA targeting the genes encoding programmed cell death protein ligand 1 (PD-L1) and PD-L2 decrease PD-L1 and PD-L2 levels in monocyte-derived dendritic cells. Formulations containing PEG(2000)-C-DMG have been used in the development of LNPs for the delivery of siRNA-based vaccines.Formal Name: (R)-142-oxo-2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80,83,86,89,92,95,98,101,104,107,110,113,116,119,122,125,128,131,134,137,143-heptatetracontaoxa-141-azahexatetracontahectane-145,146-diyl ditetradecanoate. Synonyms: PEG2000-C-DMG, Polyethylene Glycol-2000-C-DMG. Molecular Formula: C126H249NO52. Formula Weight: 2610.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CCCCCCCCCCCCCC(O[C@H](COC(CCCCCCCCCCCCC)=O)COC(NCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O. InChi Code: InChI=1S/C126H249NO52/c1-4-6-8-10-12-14-16-18-20-22-24-27-124(128)177-121-123(179-125(129)28-25-23-21-19-17-15-13-11-9-7-5-2)122-178-126(130)127-29-26-30-132-33-34-134-37-38-136-41-42-138-45-46-140-49-50-142-53-54-144-57-58-146-61-62-148-65-66-150-69-70-152-73-74-154-77-78-156-81-82-158-85-86-160-89-90-162-93-94-164-97-98-166-101-102-168-105-106-170-109-110-172-113-114-174-117-118-176-120-119-175-116-115-173-112-111-171-108-107-169-104-103-167-100-99-165-96-95-163-92-91-161-88-87-159-84-83-157-80-79-155-76-75-153-72-71-151-68-67-149-64-63-147-60-59-145-56-55-143-52-51-141-48-47-139-44-43-137-40-39-135-36-35-133-32-31-131-3/h123H,4-122H2,1-3H3,(H,127,130)/t123-/m1/s1. InChi Key: CREULCBVNNLFSX-SVNQTKKWSA-N.