Panaxadiol

Panaxadiol is a triterpenoid sapogenin that has been found in P. ginseng and has diverse biological activities. It inhibits the growth of HepG2 human hepatoma, A549 lung, MCF-7 breast, and HCT116 colon cancer cells (IC50s = 63.20, 40.88, 61.96, and 92.53 µM, respectively). Panaxadiol (30 mg/kg) reduces tumor growth in an HCT116 mouse xenograft model. It inhibits hepatitis B virus (HBV) DNA replication in HepG 2.2.15 cells with an IC50 value of 148.15 µM. Panaxadiol (50 mg/kg) also decreases the escape latency in the Morris water maze (MWM) in an APP/PS1 mouse model of Alzheimer's disease.Formal Name: 20R,25-epoxy-dammarane-3beta,12beta-diol. CAS Number: 19666-76-3. Synonyms: NSC 308879, 20(R)-Panaxadiol. Molecular Formula: C30H52O3. Formula Weight: 460.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 10 mg/ml, Ethanol: 0.25 mg/ml. SMILES: C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC2)C)O)([H])[C@]([C@@]5(OC(C)(CCC5)C)C)([H])CC3)C. InChi Code: InChI=1S/C30H52O3/c1-25(2)13-9-14-30(8,33-25)19-10-16-29(7)24(19)20(31)18-22-27(5)15-12-23(32)26(3,4)21(27)11-17-28(22,29)6/h19-24,31-32H,9-18H2,1-8H3/t19-,20+,21-,22+,23-,24-,27-,28+,29+,30+/m0/s1. InChi Key: PVLHOJXLNBFHDX-XHJPDDKBSA-N. Origin: Plant/Panax ginseng.