PAF C-18-d4

PAF C-18-d4 contains four deuterium atoms at the 9, 9', 10, and 10' positions. It is intended for use as an internal standard for the quantification of PAF C-18 by GC- or LC-mass spectrometry. PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the "remodeling" and 'de novo' pathways. It is less potent than PAF C-16 in the induction of platelet aggregation, but equipotent in activation of guinea pig macrophages. PAF C-18 induces the release of PGE2 and TXB2 from albumin-elicited guinea pig macrophages, and enhances the spreading of plated macrophages. Pathological processes involving PAF include necrotizing enterocolitis, inflammation, asthma, and allergy.Formal Name: 1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine-9,9,10,10-d4. Molecular Formula: C28H54D4NO7P. Formula Weight: 555.7. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 20 mg/ml, Water: 20 mg/ml. SMILES: O=P(OCC[N+](C)(C)C)([O-])OC[C@H](OC(C)=O)COCCCCCCCCC([2H])([2H])C([2H])([2H])CCCCCCCC. InChi Code: InChI=1S/C28H58NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3,4)5/h28H,6-26H2,1-5H3/t28-/m1/s1/i13D2,14D2. InChi Key: ZXCIEWBDUAPBJF-QRYFZMODSA-N. Side Chain Carbon Sum: 20:0.