oxLig-1 (technical grade)

oxLig-1 is an omega-carboxylated 7-ketocholesteryl ester and a lipid component of oxidized LDL (oxLDL). It binds to the ligand-binding domain of peroxisome proliferator-activated receptor gamma (PPARgamma), an effect that can be reversed by the PPARgamma agonist troglitazone (Cay-71750), and also binds to CD36, also known as scavenger receptor B2, when used at a concentration of 50 µg/ml. oxLig-1 (20 µg/ml) increases cholesterol efflux and protein levels of liver X receptor alpha (LXRalpha) and ATP-binding cassette transporter 1 subfamily A (ABCA1) in THP-1 macrophages. Liposomes containing oxLig-1 and complexed with apolipoprotein H, also known as beta2-glycoprotein I (beta2-GPI), bind to an anti-apolipoprotein H antibody, which mediates uptake by J774A.1 macrophages. oxLig-1 decreases intracellular lipid accumulation induced by oleic acid (Cay-90260, Cay-24659) in HepG2 cells, as well as hepatic lipid accumulation in mice fed a high-fat diet. Serum levels of IgG autoantibodies targeting a complex of oxLig-1 and apolipoprotein H are increased in patients with antiphospholipid syndrome with a history of arterial thrombosis.Formal Name: 3beta-[(8-carboxy-1-oxooctyl)oxy]-cholest-5-en-7-one. CAS Number: 352523-18-3. Synonyms: 7-Ketocholesteryl-9-carboxynonanoate. Molecular Formula: C36H58O5. Formula Weight: 570.8. Purity: >80%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble: 0.1-1 mg/ml. SMILES: C[C@H](CCCC(C)C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])C(C=C4C[C@@H](OC(CCCCCCCC(O)=O)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=O. InChi Code: InChI=1S/C36H58O5/c1-24(2)12-11-13-25(3)28-16-17-29-34-30(19-21-36(28,29)5)35(4)20-18-27(22-26(35)23-31(34)37)41-33(40)15-10-8-6-7-9-14-32(38)39/h23-25,27-30,34H,6-22H2,1-5H3,(H,38,39)/t25-,27+,28-,29+,30+,34+,35+,36-/m1/s1. InChi Key: YEWAZFNDLCTTDN-FJQOAEFNSA-N.