Ophiopogonin D

Ophiopogonin D is a steroid glycoside that has been found in O. japonicus tubers and has diverse biological activities. It induces apoptosis in, and reduces TGF-beta1-induced migration of, MDA-MB-231 human breast cancer cells when used at concentrations of 2.5, 5, or 10 µM. Ophiopogonin D (10 and 100 µM) inhibits hydrogen peroxide-induced production of reactive oxygen species (ROS) in RAW 264.7 cells. It inhibits peritoneal neutrophil infiltration in a mouse model of peritonitis induced by zymosan A (Cay-21175) when administered at a dose of 1 mg/kg. Ophiopogonin D (1 and 2 mg/kg) reduces thrombus weight in a mouse model of venous thrombosis.Formal Name: (1beta,3beta,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-alpha-L-mannopyranosyl-(1->2)-O-[beta-D-xylopyranosyl-(1->3)]-6-deoxy-beta-D-galactopyranoside. CAS Number: 945619-74-9. Synonyms: Deacetylophiopogonin C, OJV-V. Molecular Formula: C44H70O16. Formula Weight: 855.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 15 mg/ml. SMILES: C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@H](CO4)C)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@]6([C@@H](C[C@@H](CC6=CC5)O)O[C@H]7[C@@H]([C@H]([C@H]([C@H](O7)C)O)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)C)([H])CC2. InChi Code: InChI=1S/C44H70O16/c1-18-9-12-44(54-16-18)19(2)30-28(60-44)15-26-24-8-7-22-13-23(45)14-29(43(22,6)25(24)10-11-42(26,30)5)57-41-38(59-40-36(52)34(50)31(47)20(3)55-40)37(32(48)21(4)56-41)58-39-35(51)33(49)27(46)17-53-39/h7,18-21,23-41,45-52H,8-17H2,1-6H3/t18-,19+,20+,21-,23-,24-,25+,26+,27-,28+,29-,30+,31+,32+,33+,34-,35-,36-,37+,38-,39+,40+,41+,42+,43+,44-/m1/s1. InChi Key: FHKHGNFKBPFJCB-LYLKFOBISA-N. Origin: Plant/Ophiopogon japonicus.