nor-MC3

nor-MC3 is an ionizable cationic lipid that has been used in the generation of liposomal lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo and is a derivative of DLin-MC3-DMA (Cay-34364). Liposomal LNPs containing nor-MC3 at a molar ratio of 20:40:40:1.5 for nor-MC3:egg sphingomyelin:cholesterol:DMG-PEG(2000) compared with those with a molar ratio of 50:10:38.5:1.5 exhibit higher transfection efficiencies in vitro. Liposomal LNPs containing nor-MC3 at a molar ratio of 20:40:40:1.5 accumulate in the spleen, pancreas, heart, kidney, muscle, and inguinal lymph nodes in mice to a greater extent than those with a molar ratio of 50:10:38.5:1.5. InChI: InChI=1S/C41H75NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-40(44-41(43)38-35-39-42(3)4)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,40H,5-12,17-18,23-39H2,1-4H3/b15-13-,16-14-,21-19-,22-20- InChIKey: FJHKZFSVYMUJKI-KWXKLSQISA-N SMILES: O=C(OC(CCCCCCC/C=C\C/C=C\CCCCC)CCCCCCC/C=C\C/C=C\CCCCC)CCCN(C)C