n-Propionyl-Coenzyme A (lithium salt)

n-Propionyl-coenzyme A (n-propionyl-CoA) is a derivative of CoA (Cay-16147, Cay-21499, Cay-21722) that contains the short-chain fatty acid propionic acid. It is formed primarily by metabolism of essential amino acids and through beta-oxidation of odd-chain fatty acids. It accumulates in propionic acidemia, an autosomal recessive disorder characterized by non-functional propionyl-CoA carboxylase (PCC), the enzyme that catabolizes n-propionyl-CoA to methylmalonyl-CoA (Cay-23551). n-Propionyl-CoA is also a precursor in the synthesis of D-alpha-hydroxyglutaric acid (Cay-25895, Cay-11605) in bacteria. n-Propionyl-CoA has been used as an internal recovery standard for the quantification of HMG-CoA (Cay-25394) by HPLC. Formal Name: coenzyme A, S-propanoate, lithium salt. CAS Number: 108321-21-7. Synonyms: n-Propionyl-CoA. Molecular Formula: C24H39N7O17P3S  XLi. Formula Weight: 829.5. Purity: >90%. Formulation (Request formulation change): A solid. Solubility: Acetonitrile:Water (1:1): Sparingly Soluble: 1-10 mg/ml PBS (pH 7.2): 10 mg/ml. SMILES: O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP([O-])(O)=O.[Li+]. InChi Code: InChI=1S/C24H40N7O17P3S.Li/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31,/h11-13,17-19,23,34-35H,4-10H2,1-3H3,(H,26,32)(H,27,36)(H,40,41)(H. InChi Key: NHDDMVHJPMKFOA-IEQRABFGSA-M. Storage: -20°C. Stability: > 2 years.