N-acetyl-2-Aminophenol

N-acetyl-2-Aminophenol is a derivative of the analgesic and antipyretic acetaminophen (Cay-10024) that has been found in P. fluorescens. It inhibits platelet aggregation induced by ADP (Cay-16778, Cay-21121) or arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in isolated human platelet-rich plasma when used at a concentration of 50 µM. N-acetyl-2-Aminophenol (1 mg/kg) decreases disease severity and prevents increases in paw volume in a rat model of collagen-induced arthritis. It has been used as a synthetic intermediate in the synthesis of compounds with antimalarial activity. N-acetyl-2-Aminophenol is also a potential impurity in commercial preparations of acetaminophen.Formal Name: N-(2-hydroxyphenyl)-acetamide. CAS Number: 614-80-2. Synonyms: AAP, 2-Acetamidophenol, 2-Acetaminophenol, N-acetyl-o-Aminophenol, N-acetyl-ortho-Aminophenol, NSC 3989, Orthocetamol. Molecular Formula: C8H9NO2. Formula Weight: 151.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 16 mg/ml, DMSO: 11 mg/ml, Ethanol: Slightly soluble, PBS (pH 7.2): 0.3 mg/ml. lambdamax: 243 nm. SMILES: O=C(C)NC1=C(O)C=CC=C1. InChi Code: InChI=1S/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10). InChi Key: ADVGKWPZRIDURE-UHFFFAOYSA-N. Origin: Synthetic.