Montelukast (sodium salt)

Montelukast is a cysteinyl leukotriene 1 (CysLT1) receptor antagonist (IC50 = 4.9 nM in HEK293 cell membranes expressing the human receptor). It is selective for CysLT1 over CysLT2 receptors (IC50 = >10,000 nM in COS-7 cell membranes expressing the human receptor). Montelukast inhibits bronchoconstriction induced by leukotriene D4 (LTD4, Cay-20310) in anesthetized guinea pigs (ED50 = 69 nmol/kg, p.o.). It inhibits ovalbumin-induced airway hyperresponsiveness and increases in the number of total cells and eosinophils in bronchoalveolar lavage fluid (BALF) in a mouse model of allergic asthma when administered at doses of 3 and 10 mg/kg. Formulations containing montelukast have been used in the treatment of asthma, allergic rhinitis, and exercise-induced bronchoconstriction.Formal Name: 1-[[[(1R)-1-[3-(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]-methyl]-cyclopropaneacetic acid, monosodium salt. CAS Number: 151767-02-1. Synonyms: MK-476. Molecular Formula: C35H35ClNO3S . Na. Formula Weight: 608.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2)(1:9): .15 mg/ml, Water: 10 mg/ml. lambdamax: 212, 284, 328, 345, 359 nm. SMILES: CC(C)(O)C(C=CC=C1)=C1CC[C@@H](SCC2(CC2)CC([O-])=O)C3=CC(/C=C/C4=NC5=CC(Cl)=CC=C5C=C4)=CC=C3.[Na+]. InChi Code: InChI=1S/C35H36ClNO3S.Na/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29,/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39),/q,+1/p-1/b15-10+,/t32-,/m1./s1. InChi Key: LBFBRXGCXUHRJY-HKHDRNBDSA-M.