MK-886

MK-886 is a potent, selective inhibitor of 5-lipoxygenase-activating protein (FLAP) that prevents 5-lipoxygenase activation in vivo and inhibits leukotriene biosynthesis in leukocytes with an IC50 of 2.5 nM. In human whole blood, leukotriene biosynthesis is inhibited by MK-886 with an IC50 of 1.1 µM.Formal Name: 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid. CAS Number: 118414-82-7. Synonyms: L-663,536. Molecular Formula: C27H34ClNO2S. Formula Weight: 472.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.14 mg/ml. lambdamax: 225, 288 nm. SMILES: OC(C(C)(C)CC1=C(SC(C)(C)C)C(C=C(C(C)C)C=C2)=C2N1CC3=CC=C(Cl)C=C3)=O. InChi Code: InChI=1S/C27H34ClNO2S/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18/h8-14,17H,15-16H2,1-7H3,(H,30,31). InChi Key: QAOAOVKBIIKRNL-UHFFFAOYSA-N.