Methylcarbamyl PAF C-16

Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH. It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma. In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase. Methylcarbamyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.Formal Name: 1-O-hexadecyl-2-O-(N-methylcarbamoyl)-sn-glyceryl-3-phosphorylcholine. CAS Number: 91575-58-5. Molecular Formula: C26H55N2O7P. Formula Weight: 538.7. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 50 mg/ml, PBS pH 7.2: 25 mg/ml. SMILES: CCCCCCCCCCCCCCCCOC[C@@H](OC(NC)=O)COP(OCC[N+](C)(C)C)([O-])=O. InChi Code: InChI=1S/C26H55N2O7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-32-23-25(35-26(29)27-2)24-34-36(30,31)33-22-20-28(3,4)5/h25H,6-24H2,1-5H3,(H-,27,29,30,31)/t25-/m1/s1. InChi Key: FNFHZBKBDFRYHS-RUZDIDTESA-N.