Maresin 1-d5

Maresin 1-d5 is intended for use as an internal standard for the quantification of maresin 1 (Cay-10878) by GC- or LC-MS. Maresin 1 is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from docosahexaenoic acid (DHA, Cay-90310, Cay-17950) in human peripheral blood mononuclear cells (PBMCs). Maresin 1 (100 nM) reduces TNF-alpha-induced increases in reactive oxygen species (ROS) in primary human vascular smooth muscle and endothelial cells. It decreases disease severity, neutrophil infiltration, and intestinal crypt damage in a mouse model of colitis induced by dextran sulfate (DSS, Cay-23250) when administered at doses of 0.3 and 1 µg/animal. Maresin 1 (0.1, 1, and 10 ng/animal) inhibits increases in inflammatory exudate polymorphonuclear (PMN) neutrophil infiltration in a mouse model of peritonitis induced by zymosan A (Cay-21175). It has been found in the synovial fluid of rheumatoid arthritis patients.Formal Name: 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic-21,21,22,22,22-d5 acid. Synonyms: 7(R)-MaR1-d5, 7(R)-Maresin 1-d5. Molecular Formula: C22H27D5O4. Formula Weight: 365.5. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 0.05 mg/ml. lambdamax: 272 nm. SMILES: O[C@@H](C/C=C\C/C=C\C([2H])([2H])C([2H])([2H])[2H])/C=C\C=C\C=C\[C@H](O)C/C=C\CCC(O)=O. InChi Code: InChI=1S/C22H32O4/c1-2-3-4-5-6-10-15-20(23)16-11-7-8-12-17-21(24)18-13-9-14-19-22(25)26/h3-4,6-13,16-17,20-21,23-24H,2,5,14-15,18-19H2,1H3,(H,25,26)/b4-3-,8-7+,10-6-,13-9-,16-11-,17-12+/t20-,21-/m0/s1/i1D3,2D2. InChi Key: HLHYXXBCQOUTGK-MUCARDRFSA-N.