Lipoxin B4

Lipoxin B4 (LXB4) is a positional isomer of LXA4 (Cay-90410) produced by the metabolism of 15-HETE (Cay-34700) or 15(S)-HpETE (Cay-44720) by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4, Cay-20110) and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.Formal Name: 5S,14R,15S-trihydroxy-6E,8Z,10E,12E-eicosatetraenoic acid. CAS Number: 98049-69-5. Synonyms: LXB4. Molecular Formula: C20H32O5. Formula Weight: 352.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: >50 mg/ml, Ethanol: >50 mg/ml, PBS pH 7.2: >1 mg/ml (from 13(S)-HODE). SMILES: O[C@@H](CCCC(O)=O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCCCC. InChi Code: InChI=1S/C20H32O5/c1-2-3-8-14-18(22)19(23)15-10-7-5-4-6-9-12-17(21)13-11-16-20(24)25/h4-7,9-10,12,15,17-19,21-23H,2-3,8,11,13-14,16H2,1H3,(H,24,25)/b6-4-,7-5+,12-9+,15-10+/t17-,18+,19-/m1/s1. InChi Key: UXVRTOKOJOMENI-WLPVFMORSA-N.