Lipoxin A4 methyl ester

Lipoxin A4 (LXA4) methyl ester is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4. LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM. LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.Formal Name: 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid, methyl ester. CAS Number: 97643-35-1. Synonyms: LXA4 methyl ester, 5(S),6(R),15(S)-TriHETE methyl ester. Molecular Formula: C21H34O5. Formula Weight: 366.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 302 nm. SMILES: CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCCC(OC)=O. InChi Code: InChI=1S/C21H34O5/c1-3-4-9-13-18(22)14-10-7-5-6-8-11-15-19(23)20(24)16-12-17-21(25)26-2/h5-8,10-11,14-15,18-20,22-24H,3-4,9,12-13,16-17H2,1-2H3/b7-5-,8-6+,14-10+,15-11+/t18-,19+,20-/m0/s1. InChi Key: UBPCKDCSZPRQJP-QDCMSWGPSA-N.