Lipid U-101

Lipid U-101 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing lipid U-101 and encapsulating mRNA encoding a fusion protein composed of IL-2, a linker, and CD25 inhibit tumor growth in an MC-38 mouse xenograft model.Formal Name: bis(2-hexyldecyl) 6,6'-((3-(bis(2-hydroxyethyl)amino)propyl)azanediyl)dihexanoate. Molecular Formula: C51H102N2O6. Formula Weight: 839.4. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: Soluble: >10 mg/ml. SMILES: OCCN(CCO)CCCN(CCCCCC(OCC(CCCCCC)CCCCCCCC)=O)CCCCCC(OCC(CCCCCC)CCCCCCCC)=O. InChi Code: InChI=1S/C51H102N2O6/c1-5-9-13-17-19-25-34-48(32-23-15-11-7-3)46-58-50(56)36-27-21-29-38-52(40-31-41-53(42-44-54)43-45-55)39-30-22-28-37-51(57)59-47-49(33-24-16-12-8-4)35-26-20-18-14-10-6-2/h48-49,54-55H,5-47H2,1-4H3. InChi Key: MKIYWSRHXLMSER-UHFFFAOYSA-N.