Lipid TD5

Lipid TD5 is an ionizable cationic lipid (pKa = 7.3) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing lipid TD5 undergo endocytosis in a serotonin (5-HT) receptor subtype 1A-dependent manner in primary mouse astrocytes. Intrathecal administration of LNPs containing lipid TD5 selectively traffic to the brain over the liver and spleen in mice. InChI: InChI=1S/C45H81N3O/c1-3-5-7-9-11-13-15-17-19-21-24-30-38-48(39-31-25-22-20-18-16-14-12-10-8-6-4-2)40-32-26-23-29-37-46-45(49)36-35-42-41-47-44-34-28-27-33-43(42)44/h27-28,33-34,41,47H,3-26,29-32,35-40H2,1-2H3,(H,46,49), InChIKey: DJDVSUSUQPEWBX-UHFFFAOYSA-N, SMILES: O=C(CCC1=CNC2=C1C=CC=C2)NCCCCCCN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC