Lipid ND-O1

Artikelnummer	Größe	Manual	Lieferzeit	Preis
Cay43010-1	1 mg	-	6 - 10 Werktage*	88,00 €
Cay43010-5	5 mg	-	6 - 10 Werktage*	351,00 €
Cay43010-10	10 mg	-	6 - 10 Werktage*	658,00 €

Bei Fragen nutzen Sie gerne unser Kontaktformular.
Bestellen Sie auch per E-Mail: info@biomol.com
Größere Menge gewünscht? Bulk-Anfrage

Lipid ND-O1 is an ether-containing ionizable cationic lipid (pKa = 6.6) that has been used in the... mehr

Menü schließen

Produktinformationen "Lipid ND-O1"

Lipid ND-O1 is an ether-containing ionizable cationic lipid (pKa = 6.6) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA in vitro and in vivo. LNPs containing ND-O1 and encapsulating Cy5-labeled siRNA selectively accumulate in the liver over the spleen, heart, kidney, and lung in mice. LNPs containing ND-O1 and encapsulating siRNA targeting heat shock protein 47 (Hsp47) decrease hepatic collagen, TNF-alpha, IL-1beta, TGF-beta, and IL-6 levels in a mouse model of hepatic fibrosis induced by carbon tetrachloride (CCL4). InChI: InChI=1S/C43H85NO6/c1-4-7-10-13-17-23-30-41(31-24-18-14-11-8-5-2)50-43(47)33-26-20-16-22-28-35-44(36-37-45)34-27-21-15-19-25-32-42(46)49-40-39-48-38-29-12-9-6-3/h41,45H,4-40H2,1-3H3 InChIKey: AJCULPGBAFPOED-UHFFFAOYSA-N SMILES: O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCCCC(OCCOCCCCCC)=O)CCO

Schlagworte:	SM-86 Analog-2, heptadecan-9-yl 8-((8-(2-(hexyloxy)ethoxy)-8-oxooctyl)(2-hydroxyethyl)amino)octanoate
Hersteller:	Cayman Chemical
Hersteller-Nr:	43010

Eigenschaften

Anwendung:	Ether-containing ionizable cationic lipid, LNP generation
MW:	712.15 D
Formel:	C43H85NO6
Reinheit:	>90%
Format:	Solution

Datenbank Information

Handhabung & Sicherheit

Lagerung:	-20°C
Versand:	+20°C (International: -20°C)
Signalwort:	Warning
GHS-Piktogramme:
H-Sätze:	H302, H400, H410
P-Sätze:	P264, P270, P273, P301+310, P330, P391, P501