Lipid III-45

Lipid III-45 is an ionizable cationic lipid (pKa = 6.25). It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing lipid III-45 and encapsulating a luciferase mRNA reporter accumulate in liver and adipose tissue in mice. LNPs containing lipid III-45 have been used to deliver an mRNA sequence encoding an antibody targeting the tumor-associated antigen and tight junction integral protein claudin-18 isoform 2 (claudin-18.2) to mice and reduce tumor volume in an MDA-MB-231 mouse xenograft model.Formal Name: 2-butyl-octanoic acid, 1,1'-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester. CAS Number: 2096984-25-5. Synonyms: Cationic Lipid A. Molecular Formula: C45H89NO5. Formula Weight: 724.2. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 10 mg/ml. SMILES: OCCCN(CCCCCCCCCOC(C(CCCC)CCCCCC)=O)CCCCCCCCCOC(C(CCCC)CCCCCC)=O. InChi Code: InChI=1S/C45H89NO5/c1-5-9-13-25-34-42(32-11-7-3)44(48)50-40-29-23-19-15-17-21-27-36-46(38-31-39-47)37-28-22-18-16-20-24-30-41-51-45(49)43(33-12-8-4)35-26-14-10-6-2/h42-43,47H,5-41H2,1-4H3. InChi Key: WKWZZCCOOBPOOA-UHFFFAOYSA-N.