Lipid 88

Lipid 88 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing lipid 88 and encapsulating mRNA encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein increase anti-spike glycoprotein IgG titers in bronchoalveolar lavage fluid (BALF), as well as increase the percentage of CD8+, CD8+CD44+, CD4+, and CD4+CD44+ T cells in the lungs and spleen, in mice after two doses three weeks apart. LNPs containing lipid 88 and encapsulating mRNA expressing SARS-CoV-2 spike glycoprotein inhibit reductions in body weight, increase serum levels of anti-spike glycoprotein IgG and IgA titers, and reduce lung and nasal wash viral titers in a hamster model of SARS-CoV-2 Omicron BQ.1 subvariant infection.Formal Name: tetrakis(2-((((2-butyloctyl)oxy)carbonyl)oxy)ethyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate. CAS Number: 2982842-99-7. Molecular Formula: C79H147N3O20. Formula Weight: 1459.0. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Chloroform: Sparingly soluble: 1-10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: CCCCCCC(CCCC)COC(OCCOC(CCN(CCC(OCCOC(OCC(CCCC)CCCCCC)=O)=O)CCCN(C)CCCN(CCC(OCCOC(OCC(CCCC)CCCCCC)=O)=O)CCC(OCCOC(OCC(CCCC)CCCCCC)=O)=O)=O)=O. InChi Code: InChI=1S/C79H147N3O20/c1-10-18-26-30-40-68(36-22-14-5)64-99-76(87)95-60-56-91-72(83)44-52-81(53-45-73(84)92-57-61-96-77(88)100-65-69(37-23-15-6)41-31-27-19-11-2)50-34-48-80(9)49-35-51-82(54-46-74(85)93-58-62-97-78(89)101-66-70(38-24-16-7)42-32-28-20-12-3)55-47-75(86)94-59-63-98-79(90)102-67-71(39-25-17-8)43-33-29-21-13-4/h68-71H,10-67H2,1-9H3. InChi Key: JUWROHWTUPFLCX-UHFFFAOYSA-N.